A200 HIGH-DEFINITION CHROMOENDOSCOPY RESULTS IN MORE SIGNIFICANT DYSPLASIA DETECTION THAN WHITE LIGHT ENDOSCOPY WITH RANDOM BIOPSIES IN ULCERATIVE COLITIS PATIENTS

Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease that results in inflammation of the colonic mucosa, leading to abdominal pain, rectal bleeding, weight loss, and diarrhea. This chronic a 2.4-fold increased future risk developing colorectal cancer (CRC) UC patients compared general population. Thus, careful dysplasia screening modalities are required prevent progression CRC. Currently, both high-definition white light endoscopy with non-targeted biopsies (HD-WLR) dye-spray chromoendoscopy (HDCE) regularly used across Canada for surveillance given existing research has been inconclusive regarding superiority one particular method, recent guidelines do not suggest preference. Purpose The primary objective this study was determine which modality yielded higher detection rate patients, by calculating total number dysplastic lesions detected, as well at least lesion detected using either technique. Method We conducted single-centre retrospective chart review 150 who underwent our site between January 2019-2021. calculated techniques time first CRC colonoscopy. Result(s) Eighteen were total, three HD-WLR fifteen HDCE. Dysplasia 4% (3/75) 14.5% (15/75) HDCE respectively, significantly fewer (4.44 + 4.3 vs 29.1 13.0) required. two polypoid non-polypoid lesion, while eleven four lesions. No invisible or detected. Screening performed 10.8 4.8 9.72 3.05 years following diagnosis respectively. Median withdrawal 9.0 2.7 min 9.6 3.9min (HDCE). Image Conclusion(s) resulted rates patient Given former technique less tedious costly, findings should be considered over surveillance. Please acknowledge all funding agencies checking applicable boxes below None Disclosure Interest Declared